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The analysis on reservoir sediment deposition and downstream river channel scouring after impoundment

Lu Jinyou,Huang Yue,Wang Jun

Strategic Study of CAE 2011, Volume 13, Issue 7, Pages 129-136

Abstract:

According to the measured data after impoundment and operation of theanalysis that the reservoir sediment deposition and downstream river channel scouring during 8-year impoundment

Keywords： Three Gorges Project trial impoundment reservoir sediment deposition downstream river channel scouring

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Trial design of arch bridge of composite box section with steel web-concrete flange

Jiangang WEI, Qingwei HUANG, Baochun CHEN,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 3, Pages 370-375 doi: 10.1007/s11709-010-0073-7

Abstract: Bridge (the longest concrete arch bridge in the world with a main span of 420 m) as a prototype, trialComparison of quantities and structural behaviors of the prototype concrete arch with the two trial designed

Keywords： steel webs concrete box arch trial design structural behaviors finite element method

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Balancing method without trial weights for rotor systems based on similitude scale model

Ruiduo YE, Liping WANG, Xiaojie HOU, Zhong LUO, Qingkai HAN

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 4, Pages 571-580 doi: 10.1007/s11465-018-0478-x

Abstract:

A balancing method without trial weights based on the dynamic similitude scale model was proposedThe balancing method without trial weights was proposed based on the similitude relationship of the influenceThe effect of the balancing method without trial weights was compared with that of the traditional influence

Keywords： rotor system dynamic similitude balancing without trial weights influence coefficient

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Development and clinical trial of a novel bioactive bone cement

LEONG John, LI Zhaoyang, LU William

Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 117-126 doi: 10.1007/s11684-008-0022-1

Abstract: Strontium (Sr) and related compounds have become more attractive in the prevention and treatment of osteoporosis. Previously, we developed a novel bioactive bone cement which is mainly composed of strontium-containing hydroxyapatite (Sr-HA) filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) resin. This bone cement is superior to conventional polymethylmethacrylate (PMMA) bone cement in bioactivity, biocompatibility, and osseointegration. It also has shown sufficient mechanical strength properties for its use in percutaneous vertebroplasty (PVP) and total hip replacement (THR). In this paper, we review the and clinical evidence for the effectiveness of this bioactive bone cement.

Keywords： bioactivity effectiveness strontium-containing hydroxyapatite osseointegration sufficient mechanical

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A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: This open label, randomized, controlled, non-inferiority trial was conducted at multiple sites in China

Keywords： iron deficiency anemia intravenous iron ferric carboxymaltose iron sucrose Hb response early response

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diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Lifestyle interventions, including dietary adjustments and exercise, are important for obesity management. This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet (LCD) or exercise is more effective in metabolism improvement. Forty-five eligible subjects were randomly divided into an LCD group (n=22) and an exercise group (EX, n=23). The subjects either adopted LCD (carbohydrate intake<50 g/day) or performed moderate-to-vigorous exercise (≥30 min/day) for 3 weeks. After the interventions, LCD led to a larger weight loss than EX (−3.56±0.37 kg vs. −1.24±0.39 kg, P<0.001), as well as a larger reduction in fat mass (−2.10±0.18 kg vs. −1.25±0.24 kg, P=0.007) and waist circumference (−5.25±0.52 cm vs. −3.45±0.38 cm, P=0.008). Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance. Triglycerides decreased in both two groups, whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group. Various glycemic parameters, including serum glycated albumin, mean sensor glucose, coefficient of variability (CV), and largest amplitude of glycemic excursions, substantially declined in the LCD group. Only CV slightly decreased after exercise. This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance. Compared with exercise, LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

Keywords： low-carbohydrate diet obesity nonalcoholic fatty liver disease continuous glucose monitoring mean sensor glucose

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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 323-329 doi: 10.1007/s11684-009-0061-2

Abstract: The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

Keywords： early postmenopausal women bone mineral density exercise effects

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chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: This randomized trial involved nine centers across China.

Keywords： chemotherapy cervical cancer lymph node metastasis concurrent chemoradiotherapy quality of life

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Immunosuppression and Liver Transplantation Review

Jan Lerut, Samuele Iesari

Engineering 2023, Volume 21, Issue 2, Pages 175-187 doi: 10.1016/j.eng.2022.07.007

Abstract:

Perfect surgical techniques and adequate immunosuppression are key to ensuring optimal graft and patient survival. The availability of different drugs has led to several, often industry-driven, heterogeneous clinical trials to discover an ideal immunosuppressive regimen. However, the considerable and conceptually diverse study designs have failed to afford a clear definition of the optimal immunosuppression regimen. The triple-drug immunosuppressive regimen, based on the calcineurin inhibitor tacrolimus, antimetabolites mofetil mycophenolate or azathioprine, and short-term steroids—beyond possible induction—remains the currently accepted standard immunosuppression in liver transplantation. However, this regimen needs to be challenged in light of the changing definitions of rejection, customization of the immunosuppressive load, and long-term side effects due to chronic immunosuppression. Future trials should preferably include more than a single endpoint rather than acute T-cell-mediated acute rejection (a-TCMR) or kidney failure. Conversely, a comprehensive endpoint that covers patient and graft survival rates and the incidence of both acute and chronic rejection is warranted. These immune phenomena should be examined in light of serial long-term biological and histological follow-up. The diagnosis and treatment of clinically relevant a-TCMR should be based on integrated biological, immunological, and histopathological findings. Both elements are critical to progress toward more prudent immunosuppression handling and favor clinical operational tolerance.

Keywords： Liver transplantation Immunosuppression Rejection Tolerance Clinical trial

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Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1, Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract:

Natural killer (NK) cells are key innate immune cells that provide the first line of defense against viral infection and cancer. Although NK cells can discriminate between "self" and "non-self," recognize abnormal cells, and eliminate transformed cells and malignancies in real time, tumors develop several strategies to escape from NK cell attack. These strategies include upregulating ligands for the inhibitory receptors of NK cells and producing soluble molecules or immunosuppressive factors. Various types of NK cells are currently being applied in clinical trials, including autologous or allogeneic NK cells, umbilical cord blood (UCB) or induced pluripotent stem cell (iPSC)-derived NK cells, memory-like NK cells, and NK cell line NK-92 cells, for the treatment of different types of tumors. Chimeric antigen receptors (CARs)-NK cells have recently shown great potential due to their redirect specificity and effective antitumor activity. In this review, we summarize the mechanisms of tumor escape from NK cell recognition, the current status and advanced progress of NK cell-based immunotherapy, ways of enhancing the antitumor capacity of NK cells in vivo, and major challenges for clinical practice in this field.

Keywords： Natural killer cell Immunotherapy Cancer Clinical trial Chimeric antigen receptor

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract:

Advances in next-generation sequencing and bioinformatics have begun to reveal the complex genetic landscape in human cancer genomes, including oral squamous cell carcinoma (OSCC). Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are required to understand the molecular diversity of cancer and achieve the goal of personalized therapies. Patient-derived xenograft (PDX) models generated from human tumor samples that can retain the histological and genetic features of their donor tumors have been shown to be the preferred preclinical tool in translational cancer research compared with other conventional preclinical models. Specifically, genetically well-defined PDX models can be applied to accelerate targeted antitumor drug development and biomarker discovery. Recently, we have successfully established and characterized an OSCC PDX panel as part of our tumor bio-bank for translational cancer research. In this paper, we discuss the establishment, characterization, and preclinical applications of the PDX models. In particular, we focus on the classification and applications of the PDX models based on validated annotations, including clinicopathological features, genomic profiles, and pharmacological testing information. We also explore the translational value of this well-annotated PDX panel in the development of co-clinical trials for patient stratification and treatment optimization in the near future. Although various limitations still exist, this preclinical approach should be further tested and improved.

Keywords： patient-derived xenograft models personalized medicine co-clinical trial patient stratification oral

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methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial

Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 276-284 doi: 10.1007/s11684-021-0855-4

Abstract: In this trial (NCT01823315), 276 patients were analyzed.

Keywords： gestational trophoblastic neoplasia (GTN) methotrexate (MTX) dactinomycin (ACTD)

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and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-blind, Placebo-controlled, Pilot Clinical Trial Article

Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen

Engineering 2021, Volume 7, Issue 3, Pages 376-385 doi: 10.1016/j.eng.2020.06.026

Abstract: The study was a 12-week, randomized, double-blind, placebo-controlled, pilot clinical trial.

Keywords： Lactobacillus plantarum Irritable bowel syndrome Gut microbiota Butyric acid Clinical trial

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Feasibility of using wind turbines for renewable hydrogen production in Firuzkuh, Iran

Ali MOSTAFAEIPOUR, Mojtaba QOLIPOUR, Hossein GOUDARZI

Frontiers in Energy 2019, Volume 13, Issue 3, Pages 494-505 doi: 10.1007/s11708-018-0534-6

Abstract: appropriate turbine for electricity and hydrogen production in Firuzkuh area using the decision making trial

Keywords： wind turbine hydrogen production HOMER software decision making trial and evaluation (DEMATEL) data envelopment

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The boron neutorn capture therapy (BNCT) status to go into the new era

Zhou Yongmao

Strategic Study of CAE 2012, Volume 14, Issue 8, Pages 4-13

Abstract:

The paper briefly interprets the obvious progress of the boron neutorn capture therapy (BNCT) in the new era. It includes the BNCT clinical positioning, the tumour recurrence exploring, the boron concentration quantifed detecting, the targeting boron compound composing and the in hospitor neutron source irradintors setting up. The enlargement of these bottle necks in BNCT developing might be the preview of personalizing and routine BNCT.

Keywords： neutron capture therapy clinical trial tumour recurrence boron concentration detect targeting boron

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Title Author Date Type Operation

The analysis on reservoir sediment deposition and downstream river channel scouring after impoundment

Lu Jinyou,Huang Yue,Wang Jun

Journal Article

Trial design of arch bridge of composite box section with steel web-concrete flange

Jiangang WEI, Qingwei HUANG, Baochun CHEN,

Journal Article

Balancing method without trial weights for rotor systems based on similitude scale model

Ruiduo YE, Liping WANG, Xiaojie HOU, Zhong LUO, Qingkai HAN

Journal Article

Development and clinical trial of a novel bioactive bone cement

LEONG John, LI Zhaoyang, LU William

Journal Article

A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus

Journal Article

diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Journal Article

Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

Journal Article

chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Journal Article

Immunosuppression and Liver Transplantation

Jan Lerut, Samuele Iesari

Journal Article

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects

Yuan Hu, Zhigang Tian, Cai Zhang

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research and a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Journal Article

methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial

Journal Article

and Prevents Gut Microbiota Dysbiosis: A Randomized, Double-blind, Placebo-controlled, Pilot Clinical Trial

Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen

Journal Article

Feasibility of using wind turbines for renewable hydrogen production in Firuzkuh, Iran

Ali MOSTAFAEIPOUR, Mojtaba QOLIPOUR, Hossein GOUDARZI

Journal Article

The boron neutorn capture therapy (BNCT) status to go into the new era

Zhou Yongmao